Can you get Pregnant with Unexplained Infertility?

Unexplained infertility is infertility that is idiopathic in the sense that its cause remains unknown even after an infertility work-up, usually including semen analysis in the man and assessment of ovulation and fallopian tubes in the woman.

Dr Anu Sidana Created on 29th Dec, 20


Is there a method to become pregnant if you are facing unexplained infertility? There is no straight answer for it.

Usually, when you cannot become pregnant, the first step is testing fertility. Then, when the cause (or causes) becomes known, you must pursue treatment. If you are not ovulating, you can give Clomid a try. If sperm counts are less, your fertility specialist may recommend IVF(in vitro fertilization) or IUI (Intrauterine insemination).


What will you treat when your doctor does not understand what is wrong?

You can treat unexplained infertility through an experienced gynecologist’s observation.Dr. Anu Sidana gynecologist in Ashok Vihar, Gurgaon says at Astha infertility clinic, a treatment plan is made, and it is based on clinical experience.

Below is a common treatment map for unexplained infertility:

  1. Lifestyle changes, including weight loss, quitting smoking.
  2. Continue trying on your own (if you are young and willing) for six months to a year
  3. IUI and fertility drugs
  4. IVF treatment for three to six cycles

Below is an in-depth look at each of the approaches and odds of a successful pregnancy.


Lifestyle Changes in Unexplained Infertility Treatment

Mainly, when the cause of infertility is not known, it is vital to enhance your overall health. The recommended lifestyle changes to naturally enhance your fertility are:

  • Lose weight and exercise.
  • Stop smoking.
  • Avoid extreme alcohol consumption.
  • Cut down on caffeinated drinks.
  • Decrease stress.

However, there is no research indicating that making such changes can help you conceive. 

It is a guesswork approach to unexplained infertility treatment. Every lifestyle changes you make to boost your overall health can help.


Trying to Conceive Without Specific Fertility Treatments

You may not want to hear from your doctor to “keep trying on your own” for the next six months. Still, it can be a good plan.

After testing has confirmed your diagnosis as unexplained infertility, it is not acceptable to keep trying on your own. After your diagnosis, it is best to get some treatment since some infertility cases worsen with time. In such cases, your doctor conducts necessary fertility testing and controls the situation as you try on your own for some time. Is continuing to try the right step? Discuss your options with your doctor.


IUI and Fertility Drugs for Unexplained Infertility

If you have unexplained infertility, IUI alone or with fertility drugs can slightly raise your pregnancy odds.

In some cases, Clomid with IUI is a preferred choice over IUI with gonadotropins.

Gonadotropins are more expensive and may lead to ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies. However, they may not improve pregnancy rates adequately to justify such risks.

How many IUI cycles should you try? It depends on your age and your interest in having IVF treatment if IUI fails.

If you are open to IVF, three IUI cycles with Clomid are a good enough trial before going to IVF.

According to a study, couples who tried IUI with gonadotropins before going to IVF took longer to become pregnant and spent more money on treatment.  

If you are not willing to pursue IVF treatment, research suggests IUI with fertility drugs are worth trying for up to nine cycles.


Your best chance of Success is with IVF Treatment

When treating unexplained infertility, IVF has the best chance for a successful pregnancy.

The pregnancy rates for IVF treatment are three times more than IUI with Clomid (This can vary with age).

The pregnancy rate for Clomid with IUI is 7.6 percent, whereas the pregnancy rate per cycle for IVF is 30.7 percent. 

The success rate is high for IVF, and the “unexplained” and sometimes your specialist can discover the cause of infertility during treatment.

During IVF, your doctor may observe egg quality, the process of fertilization, and embryo development closely. However, IVF is invasive and expensive.

You may think going for an IVF is the right choice (given superior success rates). The majority of couples should give IUI with Clomid a try first.

Still, proceeding straight to IVF and skipping IUI may be the right choice if you are age 38 or older. This is something to talk with your doctor about.

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